Table 5.

Hazard Ratios for pathways from commonly mutant locations to known resistance locations

Hazard ratios; common to resistance locations
Pathway	Hazard	Confidence Bounds
43 → 103	1.92	(0.85, 4.35)
49 → 103	0.46	(0.20, 1.07)
67 → 70	4.66	(2.17, 9.99)
67 → 190	3.31	(1.70, 6.42)
68 → 184	1.93	(1.21, 3.08)
70 → 103	1.01	(0.49, 2.08)
70 → 181	0.37	(0.15, 0.92)
70 → 219	2.76	(1.61, 4.74)
74 → 184	1.84	(1.07, 3.17)
118 → 219	1.62	(0.83, 3.14)
135 → 210	0.38	(0.25, 0.59)
142 → 67	1.89	(1.13, 3.16)
162 → 70	1.89	(1.08, 3.31)
179 → 103	1.98	(0.97, 4.02)
184 → 181	1.92	(1.13, 3.27)
184 → 190	0.73	(0.39, 1.39)
196 → 103	1.87	(1.14, 3.05)
196 → 190	1.90	(0.92, 3.92)
196 → 210	0.47	(0.24, 0.93)
200 → 190	1.76	(0.92, 3.35)
210 → 70	0.12	(0.04, 0.34)
211 → 210	0.46	(0.31, 0.68)
214 → 69	2.69	(1.44, 5.03)
215 → 41	3.12	(2.05, 4.75)

Estimated hazard ratios and 95% confidence bounds for pathways leading from commonly mutant locations to locations with known association to RTI resistance. Slight discrepancies in estimated hazard ratios between this table and Table 4 are due to a different choice of regressors used to fit the model. Estimation was done using the survival [24] package of the R software environment [22].