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. 2011 Aug 26;6(8):e23536. doi: 10.1371/journal.pone.0023536

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Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Subjects underwent self-induced and externally induced squeezes in the pressure and pain conditions in a within-subjects design. Squeeze for 2 seconds/trial was repeated three times in 60 seconds. The interval between conditions was 30 seconds. All conditions were repeated three times, and condition order was randomly determined and counterbalanced. (B) During fMRI scanning, squeeze was repeated thirteen times in each condition with 10–18 seconds between trials. Each condition lasted for 180 seconds, and the interval between conditions was 60 seconds. Subjects gave off-line VAS ratings after scanning was completed.