Table 1. Possible synergistic chemopreventive effect of the interaction between Res and BTP against DMBA and TPA-induced mouse skin tumorigenesis.
| Treatment (Groups) | Tumorigenicity (%) | CNT (%) | ANT (%) | ATV (%) | ||||||||
| O | Ea | Rb | O | Ea | Rb | O | Ea | Rb | O | Ea | Rb | |
| Untreated control (I) | ||||||||||||
| DMBA+TPA (II) | 100.0 | 100.0 | 100.0 | 100.0 | ||||||||
| Acetone+Res+BTP (III) | ||||||||||||
| DMBA+TPA+Res (IV) | 64.0 | 30.9 | 47.8 | 40.5 | ||||||||
| DMBA+TPA+BTP (V) | 52.0 | 38.7 | 62.0 | 48.6 | ||||||||
| DMBA+TPA+Res+BTP (VI) | 28.0 | 33.0 | 1.17 | 10.9 | 11.9 | 1.09 | 27.1 | 30.0 | 1.08 | 18.9 | 19.7 | 1.03 |
All the data are statistically significant, p<0.01.
a
Expected value of Res and BTP combination = [(observed value of Res)/(control value)]×[(observed value of BTP)/(control value)]×(control value).
b
Ratio = (expected value/observed value). A ratio of>1 indicates a synergistic effect, and a ratio of <1 indicates a less than additive effect.
O, observed; E, expected; R, ratio; Res, resveratrol; CNT, cumulative number of tumors; ANT, average number of tumors/mouse; ATV, average tumor volume/tumor bearing mouse.