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. 2011 Jul 29;11:12. doi: 10.1186/1472-6793-11-12

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Copyright ©2011 Pacheco-Pantoja et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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P1NP levels after treatments with gut hormones in three osteoblastic cell lines. Cells were serum deprived and treated for 48 or 120 h with the gut peptides at indicated molar concentrations. Straight lines solid square markers designate 48 h treatment; dashed lines emptied square markers indicate 120 h treatment. Significant higher production of P1NP after 120 h exposure to GIP and OB were observed only in Saos-2 (C, O). The least mature cell lines, MG-63 and TE-85 showed decreased P1NP secretion in response to GIP (A), GLP-1 (D, E), GLP-2 (H) and OB (N) stimulation after 120 h exposure. In all the cases the most significant changes were observed with the lowest concentration of peptide. Results are the average of percentage of change in relation to controls; n = 5. ± SEM.