Table 1.

Comparison of pharmacokinetic parameters of tamsulosin HCl after single oral administration of 0.4 mg tamsulosin HCl with and without 20 mg paroxetine once daily co-administration

		Pharmacokinetic parameters of tamsulosin HCl
		Tamsulosin alone			Tamsulosin + paroxetine
Parameter		n	gMean	gCV (%)	n	gMean	gCV (%)
Cmax	(ng ml−1)	24	6.57	37.2	23	8.83	31.6
tmax*	(h)	24	7.00	(3.00–23.7)	23	8.00	(3.98–23.9)
AUC(0,tlast)	(ng ml−1 h)	24	107	40.5	23	165	41.8
AUC(0,∞)	(ng ml−1 h)	24	117	42.8	23	193	45.8
t1/2	(h)	24	11.4	26.4	23	15.3	24.8
MRTpo	(h)	24	20.5	24.5	23	25.6	21.9
CL/F	(l h−1)	24	3.41	42.8	23	2.07	45.8
Vz/F	(l)	24	56.4	35.0	23	45.7	37.4

^*Median (minimum–maximum)

C_max, maximum plasma concentration; t_max, time to maximum plasma concentration; AUC(0,t_last), area under the concentration–time curve from 0 to the last quantifiable data point; AUC(0,∞), area under the concentration–time curve from 0 to ∞; t_1/2, half-life; MRT, mean residence time; CL/F, apparent clearance; V_z/F, apparent volume of distribution.