Table 2.

Comparison of pharmacokinetic parameters of tamsulosin HCl after single oral administration of 0.4 mg tamsulosin HCl with and without 400 mg ketoconazole once daily co-administration

		Pharmacokinetic parameters of tamsulosin HCl
		Tamsulosin alone			Tamsulosin + ketoconazole
Parameter		n	gMean	gCV (%)	n	gMean	gCV (%)
Cmax	(ng·ml−1)	24	7.70	43.3	23	17.0	34.6
tmax*	(h)	24	6.98	(5.00–23.9)	23	7.00	(4.98–10.0)
AUC(0,tlast)	(ng ml−1 h)	24	108	58.4	23	297	42.0
AUC(0,∞)	(ng ml−1 h)	24	115	60.8	23	326	46.2
t1/2	(h)	24	10.5	25.4	23	11.8	29.3
MRTpo	(h)	24	18.2	21.8	23	21.0	25.5
CL/F	(l·h−1)	24	3.47	60.8	23	1.23	46.2
Vz/F	(l)	24	52.4	42.2	23	20.8	28.9

^*Median (minimum–maximum).

C_max, maximum plasma concentration; t_max, time to maximum plasma concentration; AUC(0,t_last), area under the concentration–time curve from 0 to the last quantifiable data point; AUC(0,∞), area under the concentration–time curve from 0 to ∞; t_1/2, half-life; MRT, mean residence time; CL/F, apparent clearance; V_z/F, apparent volume of distribution.