Table 1.

Pharmacokinetics of 5-HMT following administration of single dose fesoterodine 8 mg alone or co-administration of fesoterodine with fluconazole 200 mg^*

	Fesoterodine + fluconazole (Test)	Fesoterodine alone (Reference)	Test : reference ratio† (90% CI)
n	27	27	–
AUC(0,∞) (ng ml–1 h)	62.8	49.5	126.8 (118.3, 135.9)
AUC(0,tlast) (ng ml–1 h)	61.4	48.3	127.1 (118.7, 136.1)
Cmax (ng ml–1)	5.27	4.42	119.2 (110.8, 128.3)
tmax (h)	5.0 (2.1–6.0)	5.0 (3.0–6.0)	ND
t1/2 (h)	8.05 (35)	7.83 (40)	ND

^*AUC(0,∞), AUC(0,t_last) and C_max presented as adjusted geometric means, t_max presented as median (range), t_1/2 presented as arithmetic mean (% coefficient of variation).

^†Ratio of adjusted geometric means.

5-HMT = 5-hydroxymethyl tolterodine; CI = confidence interval; AUC(0,∞) = area under the plasma concentration–time curve from time zero to infinity; AUC(0,t_last) = area under the plasma concentration–time profile from time 0 to the time of the last quantifiable concentration (C_last); C_max = maximum plasma concentration; ND = not determined; t_max = time to C_max; t_1/2 = half-life.