Figure 1.

Doxycycline's action on MMP-9 and -3 activities in BALF of IPF patients. Equal amount of BALF protein from control subjects, IPF patients (n = 6) and doxycycline treated IPF patients (n = 6) was subjected to gelatin zymography (a) and casein (b) zymography. Control samples were collected from the noninfected portion of the lungs from IPF patients. Histogram represents proMMP-9 and proMMP-3 activity (c). Values are ± SEM of three zymograms from independent experiments. ^*P < 0.001 and ns, nonsignificant against an appropriate control