Table 3.
List of downregulated proteins in periodontitis GCF.
| # | Identified Proteins | Accession Number | Biological process | Cellular component | Molecular function | Molecular Weight | N | MP | MP/N fold | N/MP fold |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Cystatin-A | IPI00032325 | keratinocyte | cytoplasm | cysteine-type endopeptidase inhibitor activity | 11 kDa | 4.5 ± 3.5 | 2.3 ± 1.1 | 0.5 | 2.0 |
| 2 | Thymidine phosphorylase | IPI00292858 | chemotaxis | glycosyltransferase | 50 kDa | 7.5 ± 2.8 | 3.8 ± 0.4 | 0.5 | 2.0 | |
| 3 | Cystatin-B | IPI00021828 | cytoplasm nucleus | protease inhibitor | 11 kDa | 11.0 ± 5.7 | 5.3 ± 1.1 | 0.5 | 2.1 | |
| 4 | Cystatin-SN | IPI00305477 | secreted | cysteine-type endopeptidase inhibitor activity | 16 kDa | 13.5 ± 0.7 | 6.3 ± 2.5 | 0.5 | 2.2 | |
| 5 | IGKV3D-15 Myosin-reactive immunoglobulin light chain variable region | IPI00549330 | 13 kDa | 6.3 ± 0.4 | 2.8 ± 0.4 | 0.4 | 2.3 | |||
| 6 | Nucleoside diphosphate kinase B | IPI00026260 | transcription regulation | cytoplasm nucleus | kinase | 17 kDa | 6.0 ± 3.5 | 2.5 ± 1.4 | 0.4 | 2.4 |
| 7 | 14-3-3 protein epsilon | IPI00000816 | host-virus interaction | cytoplasm | histone deacetylase binding | 29 kDa | 9.0 ± 1.4 | 3.5 ± 3.5 | 0.4 | 2.6 |
| 8 | Prolactin-inducible protein | IPI00022974 | secreted | actin binding | 17 kDa | 15.0 ± 12.0 | 5.3 ± 6.0 | 0.4 | 2.9 | |
| 9 | alpha-2-glycoprotein 1, zinc | IPI00166729 | immune response | secreted | transmembrane transporter activity | 34 kDa | 13.0 ± 2.8 | 4.5 ± 2.8 | 0.3 | 2.9 |
| 10 | Polymeric immunoglobulin receptor | IPI00004573 | membrane secreted | protein binding | 83 kDa | 76.0 ± 34.6 | 25.3 ± 31.5 | 0.3 | 3.0 | |
| 11 | Lipopolysaccharide-responsive and beige-like anchor protein | IPI00002255 | cell membrane | protein binding | 319 kDa | 4.8 ± 4.6 | 1.5 ± 0.7 | 0.3 | 3.2 | |
| 12 | IGL@ protein | IPI00555945 | 25 kDa | 69.0 ± 27.6 | 21.5 ± 13.4 | 0.3 | 3.2 | |||
| 13 | Heat shock protein beta-1 | IPI00025512 | stress response | cytoplasm cytoskeleton nucleus | identical protein binding | 23 kDa | 7.8 ± 1.1 | 2.3 ± 1.8 | 0.3 | 3.4 |
| 14 | Glutathione S-transferase P | IPI00219757 | anti-apoptosis | cytoplasm | glutathione transferase activity | 23 kDa | 34.5 ± 30.4 | 10.0 ± 9.2 | 0.3 | 3.5 |
| 15 | S100-A2 | IPI00019869 | endothelial cell migration | calcium ion binding | 11 kDa | 4.5 ± 0.7 | 1.3 ± 0.4 | 0.3 | 3.6 | |
| 16 | Glutathione transferase omega-1 | IPI00019755 | cytoplasm | glutathione transferase activity | 28 kDa | 4.0 ± 1.4 | 1.0 ± 0.7 | 0.3 | 4.0 | |
| 17 | Carbonyl reductase [NADPH] 1 | IPI00295386 | oxidation reduction | cytoplasm | oxidoreductase | 30 kDa | 7.8 ± 3.2 | 1.3 ± 1.1 | 0.2 | 6.2 |
| 18 | CRISP3 cDNA FLJ75207 | IPI00004798 | extracellular region | 29 kDa | 7.0 ± 7.8 | 1.0 ± 1.4 | 0.1 | 7.0 | ||
| 19 | Isoform 1 of Serpin B3 | IPI00022204 | cytoplasm | serine protease inhibitor | 45 kDa | 4.5 ± 2.1 | 0.5 ± 0.0 | 0.1 | 9.0 | |
| 20 | Aldo-keto reductase family 1 member B10 | IPI00105407 | oxidation reduction | cytoplasm | oxidoreductase | 36 kDa | 4.8 ± 3.2 | 0.3 ± 0.4 | 0.1 | 19.0 |