Table 4.
Bootstrap Multivariate HRs for Baseline QoL Measures
| Baseline Variable | HR (95% CI) | P |
|---|---|---|
| General Quality of Life | ||
| Global | 0.93 (0.87 - 0.98) | 0.01* |
| General Function | ||
| Physical | 1.08 (0.97 - 1.22) | 0.16 |
| Role | Not used | |
| Emotional | 1.01 (0.92 - 1.10) | 0.86 |
| Cognitive | 1.02 (0.93 - 1.13) | 0.57 |
| Social | 0.93 (0.83 - 1.02) | 0.14 |
| General Symptom | ||
| Fatigue | 1.01 (0.90 - 1.10) | 0.87 |
| Nausea/Vomiting | 0.95 (0.83 - 1.05) | 0.30 |
| Pain | 1.02 (0.95 - 1.09) | 0.69 |
| Dyspnea | 1.05 (0.99 - 1.13) | 0.14 |
| Insomnia | 1.04 (0.99 - 1.12) | 0.19 |
| Appetite Loss | 1.07 (1.0 - 1.16) | 0.06 |
| Constipation | 0.94 (0.85 - 1.01) | 0.08 |
| Diarrhea | 1.01 (0.94 - 1.09) | 0.73 |
| Financial | 0.98 (0.91 - 1.05) | 0.48 |
• HRs correspond to a 10-point increment for QoL scores
• 2 sets of multivariate models were constructed: one for global QoL and other for all general function and symptom variables combined
• Multivariate model (for general function and symptom variables combined) adjusted for age, gender, stage at diagnosis, prior treatment history and all baseline QoL variables excepting role function
• Multivariate model for global QoL adjusted for age, gender, stage at diagnosis and prior treatment history
• *P < 0.05