Table 6.
Bootstrap Multivariate HRs for Change in QoL Measures
| Change Variable | HR (95% CI) | P |
|---|---|---|
| General Quality of Life | ||
| Global | 0.99 (0.94 - 1.05) | 0.85 |
| General Function | ||
| Physical | 0.86 (0.75 - 0.95) | 0.004* |
| Role | Not used | |
| Emotional | 1.01 (0.95 - 1.09) | 0.71 |
| Cognitive | 0.99 (0.91 - 1.06) | 0.75 |
| Social | 1.08 (1.02 - 1.14) | 0.01* |
| General Symptom | ||
| Fatigue | 0.98 (0.89 - 1.06) | 0.55 |
| Nausea/Vomiting | 1.03 (0.95 - 1.10) | 0.44 |
| Pain | 1.01 (0.94 - 1.07) | 0.74 |
| Dyspnea | 0.98 (0.91 - 1.05) | 0.53 |
| Insomnia | 1.0 (0.95 - 1.05) | 0.82 |
| Appetite Loss | 0.96 (0.90 - 1.02) | 0.15 |
| Constipation | 1.02 (0.98 - 1.08) | 0.36 |
| Diarrhea | 1.02 (0.98 - 1.09) | 0.36 |
| Financial | 1.01 (0.96 - 1.05) | 0.78 |
• HRs correspond to a 10-point increment for QoL scores
• 2 sets of multivariate models were constructed: one for global QoL and other for all general function and symptom variables combined
• Multivariate model (for change in general function and symptom variables combined) adjusted for age, gender, stage at diagnosis, prior treatment history and all QoL change variables excepting role function change
• Multivariate model for change in global QoL adjusted for age, gender, stage at diagnosis and prior treatment history
• *P < 0.05