Table 1.

Blood analysis results before (D0) and after (D6) 5 days administration of 5 mg/kg (Group 1) or 25 mg/kg (Group 2) of oral doxycycline BID in 2 months-old healthy Belgian Blue calves.

		Group 1 (n = 6)		Group 2 (n = 6)
	Reference range	D0 Mean ± SD	D6 Mean ± SD	D0 Mean ± SD	D6 Mean ± SD	Group 1 vs Group 2 p
AST (IU/L)	70-130	77 ± 13	77 ± 16	62 ± 19	68 ± 23	NS
LDH (IU/L)	1691-2618	2464 ± 512	2578 ± 428	2031 ± 336	2169 ± 348	NS
CK (IU/L)	128-244	270 ± 257	306 ± 27	145 ± 37	191 ± 79	NS
Iso-CK MM (%)		55 ± 17	45 ± 21	39 ± 11	47 ± 16	NS
Iso-CK BB (%)		5 ± 2	4 ± 2	5 ± 2	3 ± 1	NS
Iso-CK MB (%)		3 ± 3	3 ± 2	3 ± 1	2 ± 1	NS
Iso-CK MT (%)		37 ± 14	49 ± 18	54 ± 12	49 ± 17	NS

AST: aspartate aminotransferase; LDH: lactate dehydrogenase; CK: creatine kinase; Iso-CK MM: muscle creatine kinase isoenzyme; Iso-CK BB: brain creatine kinase isoenzyme; Iso-CK MB: heart creatine kinase isoenzyme; Iso-CK MT: mitochondrial creatine kinase isoenzyme; NS: not significant.