Table 3.
Median time to progression (TTP) and overall survival (OS) in patients stratified by above/below median baseline, and by above/below median ratio to baseline, soluble protein level.
| Endpoint and soluble protein | Median baseline level, pg/mL (N = 37) |
Median time to event, weeks | Log-rank P-value |
Hazard ratio (95% CI) |
|
|---|---|---|---|---|---|
| Patients with ≤ median baseline level (n = 19) |
Patients with > median baseline level (n = 18) |
||||
| TTP | |||||
| VEGF-A | 54.9 | 21.0 | 34.0 | 0.0941 | 2.15 (0.88, 5.25) |
| VEGF-C | 822.2 | 7.93 | 34.00 | 0.0096* | 4.12 (1.41, 12.02) |
| sVEGFR-2 | 7068 | 11.71 | 34.00 | 0.1641 | 1.84 (0.78, 4.33) |
| OS | |||||
| VEGF-C | 822.2 | 18.57 | 45.00 | 0.0165* | 2.53 (1.19, 5.41) |
| sVEGFR-3 | 48,700 | 57.00 | 24.64 | 0.0673 | 0.50 (0.24, 1.05) |
| Endpoint, soluble protein, and time point | Median ratio to baseline | Median time to event, weeks |
Log-rank P-value |
Hazard ratio (95% CI) |
|
|
Patients with ≤ median ratio to baseline† |
Patients with > median ratio to baseline† |
||||
| TTP | |||||
| VEGF-A | |||||
| C1D14:D1 | 2.2269 | 34.0 | 11.7 | 0.0225* | 0.30 (0.11, 0.84) |
| C2D1:D1 | 0.9153 | 42.9 | 32.4 | 0.1341 | 0.44 (0.15, 1.29) |
| C2D28:D1 | 2.0923 | 42.9 | 21.0 | 0.0034* | 0.15 (0.04, 0.53) |
| VEGF-C | |||||
| C2D1:D1 | 0.6596 | 32.43 | 11.71 | 0.0347* | 0.29 (0.09, 0.92) |
| C5D28:D1 | 0.6385 | 48.43 | 34.07 | 0.0192* | 0.16 (0.04, 0.74) |
| sVEGFR-3 | |||||
| C1D28:D1 | 0.2195 | 16.14 | 46.29 | 0.0028* | 5.54 (1.80, 17.02) |
| sKIT | |||||
| C1D14:D1 | 0.8221 | 34.14 | 16.14 | 0.0476* | 0.33 (0.11, 0.99) |
| C2D28:D1 | 0.4067 | 22.00 | 42.86 | 0.1182 | 2.35 (0.80, 6.84) |
| OS | |||||
| VEGF-A | |||||
| C1D14:D1 | 2.2269 | 69.00 | 18.79 | 0.0142* | 0.36 (0.16, 0.82) |
| C2D1:D1 | 0.9153 | 57.00 | 22.21 | 0.0862 | 0.45 (0.18, 1.12) |
| VEGF-C | |||||
| C1D28:D1 | 0.7388 | 45.00 | 21.21 | 0.0291* | 0.37 (0.15, 0.90) |
| C2D1:D1 | 0.6596 | 57.00 | 18.57 | 0.0452* | 0.38 (0.15, 0.98) |
| sVEGFR-2 | |||||
| C1D28:D1 | 0.4558 | 20.50 | 71.21 | 0.0041* | 3.96 (1.55, 10.12) |
| sKIT | |||||
| C1D14:D1 | 0.8221 | 45.00 | 27.50 | 0.1356 | 0.55 (0.25, 1.21) |
| C2D28:D1 | 0.4067 | 40.79 | 73.43 | 0.0218* | 0.37 (1.21, 11.48) |
Only results where P ≤ 0.2 are shown
*Significant at the 0.05 level
†Number of patients included in ≤ median and > median stratification groups, respectively, at each time point: C1D14:D1: n = 17, n = 16; C1D28:D1: n = 14, n = 14; C2D1:D1: n = 13, n = 12; C2D28:D1: n = 10, n = 9; C5D28:D1: n = 6, n = 6
C, cycle; D, day