Table 5.
Multivariate analysis of variables with significant relationships with clinical outcome in univariate analysis using the Cox proportional hazard model
| Variable | n | Hazard ratio (95% CI) | Log-rank P-value |
|---|---|---|---|
| Time to progression | 37 | ||
| ECOG PS (0 vs. 1) | 2.692 (0.987-7.34) | 0.053 | |
| Baseline VEGF-C (ng/mL)† | 0.414 (0.181-0.95) | 0.037* | |
| Overall survival | 28 | ||
| Child-Pugh class (A vs. B) | 4.053 (1.011-16.25) | 0.0480* | |
| ECOG PS (0 vs. 1) | 4.875 (1.647-14.43) | 0.0042* | |
| sVEGFR-2 ratio to baseline at C1D28† | 0.0257 (0.0001-0.681) | 0.0290* |
Hazard ratio < 1 indicates that risk decreases with increasing value
*Significant at the 0.05 level
†Analyzed as continuous variables
ECOG PS, Eastern Cooperative Oncology Group performance status