Table 4.

Comparison of the accessible surface area (ASA) values of atypical amino acid replacement sites with those of all sites in gapless alignments

	Skewness of atypical replacement samples to positions in the protein globule
	Interior positions in globule (p)*			Surface positions in globule (p)*
Cyclin families	DSSP ASA values	10 ASA classes	3 ASA classes	DSSP ASA values	10 ASA classes	3 ASA classes
A animal	0.9966	0.9957	0.9906	0.0034	0.0043	0.0095
B animal	0.9570	0.9772	0.9678	0.0432	0.0230	0.0324
B fungal	0.6029	0.7785	0.7500	0.3983	0.2224	0.2512
B3 animal	0.9914	0.9975	0.9827	0.0087	0.0025	0.0175
D animal	0.9713	0.9200	0.8835	0.0289	0.0805	0.1173
E animal	0.9995	0.9999	0.9999	0.0005	0.0001	0.0001

*Distribution skewness was estimated using one-tailed Mann-Whitney's test.

p ≤ 0.005 is in bold, 0.005 <p ≤ 0.025 is in italics; Bonferonni's correction for simultaneous testing of two statistical hypotheses based on the same dataset: accessible surface area and atypical amino acid replacements positions.