Table 3.

Combined analysis of IL-6, IL-4 and TNF-α genotypes among INS patients and controls

Genotype	Patient’s N = 150 (%)	Controls N = 569 (%)	P value	OR (95% CI)
Double: IL-4-C590T + IL-6-G174C
IL-4 (1) & IL-6 (1)	48 (32.0)	361 (63.4)	Reference genotype
IL-4 (1) & IL-6 (0)	45 (30.0)	36 (6.3)	<0.001*	9.40 (5.52–16.00)
IL-4 (0) & IL-6 (1)	34 (22.7)	154 (27.1)	0.036*	1.66 (1.03–2.60)
IL-4 (0) & IL-6 (0)	23 (15.3)	18 (3.2)	<0.001*	9.61 (4.84–19.09)
Double: IL-4-C590T + TNF-α-G308A
IL-4 (1) & TNF-α (1)	70 (46.7)	345 (60.6)	Reference genotype
IL-4 (1) & TNF-α (0)	23 (15.3)	52 (9.1)	0.005*	2.18 (1.25–3.79)
IL-4 (0) & TNF-α (1)	48 (32.0)	153 (26.9)	0.038*	1.55 (1.02–2.34)
IL-4 (0) & TNF-α (0)	09 (6.0)	19 (3.3)	0.041*	2.34 (1.01–5.38)
Double: IL-6-G174C + TNF-α-G308A
IL-6 (1) & TNF-α (1)	64 (42.7)	456 (80.1)	Reference genotype
IL-6 (1) & TNF-α (0)	18 (12.0)	59 (10.4)	0.008*	2.17 (1.21–3.92)
IL-6 (0) & TNF-α (1)	54 (36.0)	42 (7.4)	<0.001*	9.16 (5.66–14.82)
IL-6 (0) & TNF-α (0)	14 (9.3)	12 (2.1)	<0.001*	8.31 (3.68–18.77)
Triple: IL-4-C590T + IL-6-G174C + TNF-α-G308A
IL-4 (1) + IL-6 (1) + TNF-α (1)	35 (23.3)	320 (56.2)	Reference genotype
IL-4 (0) + IL-6 (0) + TNF-α (1)	19 (12.7)	18 (3.2)	<0.001*	9.65 (4.64–20.09)
IL-4 (0) + IL-6 (1) + TNF-α (0)	05 (3.3)	19 (3.3)	0.090	2.40 (0.85–6.84)
IL-4 (0) + IL-6 (1) + TNF-α (1)	29 (19.3)	135 (23.7)	0.011*	1.96 (1.15–3.34)
IL-4 (1) + IL-6 (0) + TNF-α (0)	10 (6.7)	12 (2.1)	<0.001*	7.62 (3.07–18.91)
IL-4 (1) + IL-6 (0) + TNF-α (1)	35 (23.3)	24 (4.2)	<0.001*	13.33 (7.13–24.93)
IL-4 (1) + IL-6 (1) + TNF-α (0)	13 (8.7)	40 (7.1)	0.002*	2.97 (1.45–6.08)
IL-4 (0) + IL-6 (0) + TNF-α (0)	04 (2.7)	01 (0.2)	<0.001*	36.57 (3.97–336.5)

0 mutant + heterozygous, 1 wild type genotype

* Significant value (P < 0.05)