Table 4.
Distribution of IL-6-G174C, IL-4-C590T and TNF-α-G308A genotypes and alleles among idiopathic nephrotic syndrome patients
| Genotype | Steroid resistant | Steroid sensitive | P value | OR (95% CI) |
|---|---|---|---|---|
| N = 35 (%) | N = 115 (%) | |||
| IL-6-G174C (db SNP ID rs1800795) polymorphism | ||||
| Genotype frequency | ||||
| GG | 17 (48.6) | 65 (56.5) | Reference genotype | |
| GC | 14 (40.0) | 49 (42.6) | 0.828 | 1.09 (0.49–2.43) |
| CC | 04 (11.4) | 01 (0.9) | 0.002* | 15.29 (1.60–146.0) |
| Allele frequency | ||||
| Allele G | 48 (68.6) | 179 (77.8) | Reference allele | |
| Allele C | 22 (31.4) | 51 (22.2) | 0.114 | 1.61 (0.89–2.91) |
| IL-4-C590T (db SNP ID rs2243250) polymorphism | ||||
| Genotype frequency | ||||
| CC | 22 (62.8) | 71 (61.7) | Reference genotype | |
| CT | 09 (25.8) | 42 (36.6) | 0.401 | 0.69 (0.29–1.64) |
| TT | 04 (11.4) | 02 (1.7) | 0.020* | 6.46 (1.11–37.66) |
| Allele frequency | ||||
| Allele C | 53 (75.7) | 184 (80.0) | Reference allele | |
| Allele T | 17 (24.3) | 46 (20.0) | 0.440 | 1.28 (0.68–2.42) |
| TNF-α-G308A (db SNP ID rs1800629) polymorphism | ||||
| Genotype frequency | ||||
| GG | 25 (71.5) | 93 (80.9) | Reference genotype | |
| GA | 06 (17.1) | 21 (18.2) | 0.905 | 1.06 (0.39–2.92) |
| AA | 04 (11.4) | 01 (0.9) | 0.002* | 14.88 (1.59–139.2) |
| Allele frequency | ||||
| Allele G | 56 (80.0) | 207 (90) | Reference allele | |
| Allele A | 14 (20.0) | 23 (10) | 0.025* | 2.25 (1.09–4.66) |
* Significant value (P < 0.05)