Table 1.

Subject Inclusion and Exclusion

Inclusion Criteria for High-Risk Ocular Hypertension and Early Glaucoma Cohort*

History of glaucoma treatment

History of migraine

Reynaud’s syndrome or vasospasm

African-American ancestry

Age > 70 years

History of systemic hypertension

Diet-controlled diabetes

Visual field loss (Abnormal GHT or PSD (p < .05%)), with Mean Deviation (MD) better than −6 dB   at baseline.

Exclusion Criteria

Other previous or current ocular pathology

Previous ocular surgery (except successful cataract surgery)

Prior neurological surgery or disease

Visual acuity worse than 20/40 in either eye

Refractive error worse than ±5.00 D sphere and 2.00 D cylinder

Diabetes requiring medication

Additional Exclusion Criteria for Normal Comparison Cohort

Abnormal GHT test: SAP 24-2 program

Cup-disc ratio asymmetry > 0.2

Possible neuroretinal rim thinning, notching, narrowing

Disc hemorrhage

^*Subjects in the High-Risk Ocular Hypertension and Early Glaucoma cohort were required to have one or more of the listed inclusion criteria. GHT = Glaucoma Hemifield Test; PSD = Pattern Standard Deviation; SAP = standard automated threshold perimetry