Table 1.
Permeability (Peff) of AT1a antagonists across the excised mouse intestinal segments in Ussing chamber (× 106 cm/s)
| Drug | Peff (× 106 cm/s)
|
||
|---|---|---|---|
| Normal or DSS | Colon (mean ± SD) | Small intestine (mean ± SD) | |
| Losartan | Normal | 6.40 ± 5.60 | 4.21 ± 1.67 |
| DSS | 5.77 ± 3.37 | 5.24 ± 1.40 | |
| Candesartan | Normal | 4.13 ± 3.04 | 7.85 ± 5.91 |
| DSS | 5.94 ± 4.41 | 3.85 ± 2.03 | |
| DCL | Normal | 1.58 ± 1.24 | 1.37 ± 0.15 |
| DSS | 2.66 ± 0.96 | 1.52 ± 1.31 | |
| Enalaprilata | Normal rat jejunum | 6.0 | |
| Metoprolola | Normal rat jejunum | 35.0 | |
a
Enalaprilat and metoprolol permeability in Ussing chambers are listed for comparison from a previous publication [34]