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. Author manuscript; available in PMC: 2012 Aug 25.
Published in final edited form as: Neuron. 2011 Aug 25;71(4):656–670. doi: 10.1016/j.neuron.2011.06.007

Figure 4. G9a Repression in NAc Promotes Susceptibility to Stress.

Figure 4

(A) Time-course of Cre-mediated G9a knockdown in NAc and subsequent sub-maximal (8 days) social defeat stress. (B) Immunohistochemical and (C) western blot validation of G9a knockdown in NAc using HSV-Cre-GFP viruses in G9afl/fl mice. (D) G9a repression in NAc enhances social avoidance in a social interaction test. (E) G9a depletion in NAc promotes anhedonia as measured by sucrose preference. * indicates a significant difference from control condition (defeated mice infected with GFP), p<0.05. Data are presented as average ± SEM, n = 6–7/group. (E) G9a knockdown does not affect locomotor activity in an open field.