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. Author manuscript; available in PMC: 2012 Aug 25.
Published in final edited form as: Neuron. 2011 Aug 25;71(4):656–670. doi: 10.1016/j.neuron.2011.06.007

Figure 7. Local Knockdown of Endogenous CREB in NAc Promotes Antidepressant-like Behavioral Phenotypes.

Figure 7

(A) Time-course of CREB knockdown in Crebfl/fl mice and subsequent analyses of depression associated behaviors. (B) Immunohistochemical validation of CREB knockdown in Crebfl/fl mice using AAV-Cre-GFP viruses. (C) Quantification of double labeled GFP and CREB positive cells in NAc following knockdown in Crebfl/fl mice using AAV-Cre-GFP viruses. *** indicates a significant difference from AAV-GFP, p<0.001, n = 5/group. (D) Viral-mediated knockdown of CREB in NAc reduces social avoidance behavior following chronic (10 days) social stress. (E) Knockdown of CREB in NAc decreases the duration of immobility in the forced swim test. (F) Knockdown of CREB in NAc increases sucrose preference without affecting total levels of fluid (sucrose plus water) intake. * indicates a significant difference from control condition (defeated mice infected with GFP), p<0.05, n = 6–8/group. Data are presented as average ± SEM.