. Author manuscript; available in PMC: 2012 Sep 1.

Published in final edited form as: Clin Chest Med. 2011 Jul 12;32(3):469–479. doi: 10.1016/j.ccm.2011.05.001

Table 2.

Comparative Validations of Severity Models

	Phua⁶⁶	Charles⁵¹	Yandiola⁶⁹	Brown⁵²
ATS2007 (AUC)	0.85	NA	NA	0.88
SMART-COP (AUC)	NA	0.87	NA	0.83
CURXO (AUC)	NA	NA	0.75	0.83
CURB-65 (AUC)	0.68	0.67	0.61	0.76
Primary outcome	ICU admission^a	Intensive therapy^b	ICU admission^a	Intensive therapy^c and ICU admission
Sample size (Total:SCAP)	1017: >91	882:91	671:57^d	1540:298

Evaluated multiple outcomes; results generally consistent

Mechanical ventilation or vasopressor therapy

Mechanical ventilation, vasopressor therapy, emergent renal replacement, high-volume fluid resuscitation, inspired oxygen fraction > 60%

External validation cohort

AUC: Area under the Receiver-Operator Characteristic Curve; SCAP: Severe Community-Acquired Pneumonia