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. Author manuscript; available in PMC: 2011 Aug 28.
Published in final edited form as: Mol Psychiatry. 2007 Jul 10;13(5):531–543. doi: 10.1038/sj.mp.4002035

Table 3.

Comparison of haplotype frequency distributions between cases and controls

Haplotypes Controls AD DD CD OD
6 OPRD1 Tag SNPsa (2-3-6-9-10-11) n = 429 n = 541 n = 245 n = 213 n = 103
TTAATA 0.243 0.255 0.252 0.254 0.294
TTAACT 0.133 0.115 0.120 0.119 0.119
TCCGTA 0.122 0.118 0.117 0.118 0.093
TCCACT 0.059 0.051 0.060 0.047 0.068
TTCATA 0.056 0.056 0.047 0.055 0.033
TTAACA 0.048 0.046 0.032 0.039 0.015
GCAACTb 0.047 0.093 0.106 0.091 0.134
TCAATA 0.043 0.041 0.036 0.034 0.039
GCAATA 0.043 0.033 0.031 0.030 0.032
TCCGCT 0.038 0.020 0.022 0.023 0.012
TCCATA 0.035 0.028 0.031 0.036 0.027
TCAACT 0.028 0.033 0.028 0.035 0.019
TCCGCA 0.024 0.030 0.028 0.031 0.024
aP (by EM)c 0.10 0.18 0.49 0.005
All 7 OPRK1 SNPs (1-2-3-4-5-6-7) n = 329 n = 310 n = 190 n = 163 n = 89
GGTTTCT 0.448 0.402 0.399 0.391 0.411
GGCTTCTd 0.186 0.254 0.231 0.243 0.235
GGCCCTC 0.099 0.065 0.081 0.088 0.088
AGCCTCT 0.077 0.071 0.065 0.064 0.054
GGCCTCT 0.060 0.067 0.067 0.064 0.047
GTCCTCT 0.051 0.043 0.043 0.049 0.033
GTCCTTT 0.030 0.022 0.027 0.026 0.049
aP (by EM)c 0.33 0.82 0.78 0.61

Abbreviations: AD, alcohol dependence; CD, cocaine dependence; Con, normal controls; DD, drug dependence; EM, expectation–maximization; OD, opioid dependence; SNP, single nucleotide polymorphism.

a

Six OPRD1 Tag SNPs were selected by Tagger in Haploview from 11 OPRD1 SNPs.

b

OPRD1 haplotye GCAACT was significantly more frequent in AD (χ2 = 14.82, d.f. = 1, P < 0.001), CD (χ2 = 9.19, d.f. = 1, P = 0.002) and OD (χ2 = 20.68, d.f. = 1, P < 0.001) subjects than in controls.

c

Global adjusted P-values were obtained by the EM algorithm.

d

OPRK1 haplotype GGCTTCT was significant more frequent in AD subjects than in controls (χ2 = 8.12, d.f. = 1, P = 0.004). n, number of subjects (those without genotype data for more than three OPRD1 tag SNPs were not included in OPRD1 haplotype analyses; those without genotype data for more than four OPRK1 SNPs were not included in OPRK1 haplotype analyses).

Note: Rare haplotypes (frequency < 2%) of OPRD1 and OPRK1 are not listed in the table. Statistically significant P-values are in bold.