. Author manuscript; available in PMC: 2011 Aug 28.

Published in final edited form as: J Gerontol A Biol Sci Med Sci. 2005 Apr;60(4):471–475. doi: 10.1093/gerona/60.4.471

Table 2.

Comparison of Nondiabetics and Diabetics on Average (SD) Number of NPs and NFTs^*

AD Neuropathology	CERAD Neuropathological Categories 1–4^†			All CERAD Neuropathological Categories^‡
AD Neuropathology	Nondiabetics	Diabetics	Analysis of Covariance^*	Nondiabetics	Diabetics	Analysis of Covariance^*
Cerebral Cortex
N	230	38		324	61
NPs	11.62 (8.72)	7.48 (8.77)	F = 7.23; df = 1,263, p = .008; r = −.16	9.38 (8.69)	6.02 (8.73)	F = 7.59; df = 1,380, p = 0.006; r = −.14
NFTs	14.65 (7.92)	11.86 (7.96)	F = 4.00; df = 1,263, p = .047; r = −.12	12.31 (8.44)	9.52 (8.47)	F = 5.57; df = 1,380, p = .019; r = −.12
Hippocampus
N	230	35		324	55
NPs	1.38 (0.88)	0.99 (0.88)	F = 5.59; df = 1,260; p = .019; r = −.14	1.14 (0.92)	0.79 (.92)	F = 7.03; df = 1,374, p = 0.008; r = −.13
NFTs	2.18 (0.91)	1.90 (0.91)	F = 3.05; df = 1,262; p = .082; r = −.10	1.95 (0.97)	1.65 (0.97)	F = 4.79; df = 1,376, p = .029; r = −.11

Notes:

Controlling for APOE4, Clinical Dementia Rating score, and age at death.

^†

No neuropathology or only AD neuropathology.

^‡

All subjects: with no neuropathology, AD-related neuropathology, non-AD-related neuropathology, or a combination of AD-related and non-AD-related neuropathology.

SD = standard deviation; NP = neuritic plaque; NFT = neurofibrillary tangle; AD = Alzheimer’s disease; CERAD = Consortium to Establish a Registry for Alzheimer’s disease (AD).