Events 1, 3, and 4 (open arrows): fever, arthralgias, and absolute neutropenia. Events 2, 5, 6, and 7 (closed arrows): manifestations of ANCA-associated vasculitis.
Event 2: inflammatory ankle effusion and neutropenia.
Event 5: cutaneous leukocytoclastic vasculitis, fevers, and arthralgias.
Event 6: sensorineural hearing loss.
Event 7: epididymitis, fever, and absolute neutropenia.
Anti-proteinase 3 titers ranged from 359–1689 units (normal< 2.8 units).
Anti-myeloperoxidase titers ranged from 250–18452 units (normal< 20 units).
ANC = absolute neutrophil count; ANCA = antineutrophil cytoplasmic antibodies.