Table 1.

Effect of FeO or FeD on various metals in the Choroid Plexus, Brain Parenchyma, Serum, and CSF.

	Choroid Plexus (μg/g tissue)			Brain Parenchyma (μg/g tissue)
Metals	Control	Fe-Overload	Fe-Deficient	Control	Fe-Overload	Fe-Deficient
Ca43	40.60 ± 17.20	81.70 ± 61.60	210.0 ± 222.0 A	40.40 ±13.30	79.00 ± 15.10 A	67.90 ± 24.40 A
Mn55	0.081 ± 0.040	0.168 ± 0.201	0.230 ± 0.121	0.024 ±0.010	0.038 ± 0.010	0.042 ± 0.014A
Co59	0.027 ± 0.017	0.034 ± 0.008	0.053 ± 0.015 A	0.002 ± 0.003	0.004 ± 0.005	0.004 ± 0.005
Ni60	0.053 ± 0.025	0.092 ± 0.028	0.146 ± 0.088 A	0.003 ± 0.002	0.006 ± 0.002	0.0070 ± 0.004 B
Zn66	11.70 ± 3.400	17.80 ± 6.000	26.60 ± 7.400 A	1.020 ± 0.530	1.980 ± 0.830 A	1.760 ± 0.550
Se82	0.387 ± 0.110	0.605 ± 0.145	0.865 ± 0.253 A	0.017 ± 0.007	0.034 ± 0.017 A	0.030 ± 0.012
Rb85	0.480 ± 0.160	0.519 ± 0.140	1.110 ± 0.320 A	0.029 ±0.011	0.037 ± 0.017	0.039 ± 0.014
Sr88	0.005 ± 0.02370	0.051 ± 0.113	0.057 ± 0.050	0.024 ±0.006	0.046 ± 0.012 A	0.036 ± 0.008 A
	Serum (μg/L)			CSF(μg/L)
Metals	Control	Fe-Overload	Fe-Deficient	Control	Fe-Overload	Fe-Deficient
Ca43	131000 ± 21200	152000 ± 20400	133000 ± 14400	37800 ± 18200	46800 ± 24700	50000 ± 14600
Mn55	0.663 ± 0.618	1.330 ± 1.030	0.524 ± 0.452	3.200 ± 0.820	1.650 ± 2.890	14.90 ± 17.90
Co59	0.529 ± 0.084	0.488 ± 0.053	0.672 ± 0.106 A	0.471 ± 0.146	0.401 ± 0.239	0.378 ± 0.047
Ni60	5.580 ± 4.220	4.490 ± 1.540	5.440 ± 1.700	3.470 ± 2.160	2.030 ± 1.280	1.970 ± 0.560
Zn66	1720 ± 390.0	1580 ± 390.0	1950 ± 458.0	162.0 ± 74.00	112.0 ± 48.00	142.0 ± 53.00
Se82	973.0 ± 283.0	855.0 ± 213.0	969.0 ± 255.0	25.30 ± 13.60	22.70 ± 9.390	39.40 ± 7.090 A
Rb85	124 ± 61	72.80 ± 30.90 B	82.40 ± 10.80	13.10 ± 5.600	9.910 ± 4.820	14.80 ± 3.20
Sr88	28.6 ± 5.6	15.30 ± 2.400 B	21.20 ± 4.800 B	6.630 ± 3.2900	2.900 ± 1.840 B	6.300 ± 2.410

Serum, CSF, capillary depleted brain parenchyma, and choroid plexus tissues were collected and analyzed for metal content via ICP-MS. Data represent mean ± SD (n=6).

^Asignificant increase;

^Bsignificant decrease relative to control.