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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Anat Rec (Hoboken). 2010 Nov;293(11):1971–1983. doi: 10.1002/ar.21242

Figure 3. WT1 and Pax2 staining of sequential stages of kidney development in rhesus monkeys.

Figure 3

Pax2 expression was noted from the early first trimester through the late third trimester in the mesonephros (Fig. 3A), ureteric bud (UB) (Fig. 3B), condensed mesenchyme (CM) (Fig. 3C-H), and renal vesicle (RV) (Fig. 3C) of the nephrogenic zone. Isolated collecting duct (CD) cells (Fig. 3I) continued to express Pax2 postnatally; this marker was also noted in widely scattered pockets of cells under the cortical capsule (Fig. 3I-J; 3-6 months postnatal WT1/Pax2 composite images). WT1 was expressed in the genital ridge between the aorta (A) and the mesonephros (Fig. 3A) and in the metanephric mesenchyme (MM) (Fig. 3B) in the mid-first trimester, followed by the C- and S-shaped bodies (CB and SB, respectively) (Fig. 3C-G), arterioles (a), and the visceral epithelium (VE) of the glomerulus where it was co-expressed with Pax2. The parietal epithelial layer (PE) did not express WT1 but showed isolated Pax2-positive cells that were closely associated with the vascular or urinary pole of the glomerulus (g) (Fig. 3E-G). Images oriented with the cortex to the upper left (Fig. 3C-K). NT, neural tube; NC, notochord; PT, proximal tubule.