Table 2.
Summary of distribution of renal developmental markers in fetal rhesus monkeys
| MM | UB | CM | Renal vesicle |
C- shaped |
S- shaped |
Prenatal glomerulus |
Postnatal glomerulus |
CD | V | |
|---|---|---|---|---|---|---|---|---|---|---|
| WT1 | ++ | − | − | − | ++ | + |
++VE, +++P |
++P | − | +AA |
| Pax2 | − | ++ | ++ | +++ | + | + | +PE,+VE |
+/−PE, +/− VE |
+/− | − |
| Nestin | ++ | − | − | − | − | + | ++P | +P | − | +AA |
| Synaptopodin | − | +/− | − | − | − | + | ++P | +P | − | − |
| α-SMA | + | − | − | − | − | + | +/−EN, +M | − | − | +SM |
| Gremlin | − | +/− | − | − | − | + | +EN, +M | − | − | − |
WT1=Wilm’s tumor 1; Pax2=paired box 2; α-SMA=alpha-smooth muscle actin.
MM=metanephric mesenchyme; UB=ureteric bud; CM=condensed mesenchyme; CD, collecting duct; V, vasculature excluding glomerular endothelium.
VE=visceral epithelium; PE=parietal epithelium; P=podocytes; AA=afferent arterioles; EN=glomerular endothelium; M=mesangial cells; SM=vascular smooth muscle.
Qualitative expression of each marker represented by + (dim expression), ++ (moderate expression), +++ (strong expression), +/− (variable expression), − (no expression).