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. Author manuscript; available in PMC: 2011 Aug 28.
Published in final edited form as: Cell Signal. 2010 Jan 13;22(5):821–827. doi: 10.1016/j.cellsig.2010.01.006

Fig. 4.

Fig. 4

Delayed activation of ERK1/2 by LRRK2 mutant G2019S. (A) HEK293 cells were transfected with wild-type and G2019S mutant LRRK2 for 12, 24 and 48 h and subjected to immunoblot analysis. The samples were probed for activated phospho-ERK1/2 and total ERK1/2. (B) Relative band intensities for phospho-ERK1/2 immunoreactivity in wild-type, G2019S and kinase-dead LRRK2 at the indicated time points after transfection. Each value is averaged from 4 independent experiments. Mock = cells transfected with the empty vector pCI/HA.