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In vitro drug release from the intermediate NH2-SL-TGX. NH2-SL-TGX underwent self-cyclization to release the parent drug TGX-D1. The dipeptide Ser-Leu self-cyclizes to form DKP in a neutral pH. (A) Illustration of the self-cyclization reaction. (B) HPLC chromatogram monitored at 268nm. (C) Release profile of TGX-D1 from NH2-SL-TGX. The results are represented as the mean ± SD (n=3).
