Table 1.

Criteria followed for evaluate signs and symptoms of adverse reactions

Adverse symptoms/reactions	Source	Criteria
Phlebitis	Medical records	Indicated by medical personnel
Nephrotoxicity	Medical records/Laboratorial analysis	Serum creatinine concentrations of 0.5 mg/dl or 50% increase over the baseline, whichever is the higher value14
Neutropenia	Medical records/Laboratorial analysis	Neutrophil count below 1,000 cells per cm3 of peripheral blood1
Ototoxicity	Medical records	Indicated by medical personnel after audiometric evaluations and reports of hearing loss after treatment, obtained by attending physicians in the process of anamnesis;
Thrombocytopenia	Medical records/Laboratorial analysis	Platelet count less than 100,000 per microliter of peripheral blood
Red man syndrome	Medical records	Indicated by attending physicians and reviewers, faced with the following standard of diagnosis: flushing, itching, chest pain, muscle spasm or hypotension during infusion of vancomycin