Figure 5.

High resolution analysis of changes in mBP (top) and in HR (bottom) in a diabetic rat (red) from Cadre 3 for trials conducted during the 11th month after it converted and corollary analysis for an age-matched control (black). Inserts are group averages as in Figures 2 and 4. The C₁ mBP increase was not evoked by presentation of CS+ in the diabetic rat, and the C₂ pressor event and concomitant HR slowing were small in the diabetic vs. control. Mean arterial BP dropped after shock delivery in the diabetic subjects. The lack of a C₁ pressor response is consistent with the development of diabetic sympathetic dysfunction by ∼1 year of disease duration.