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. Author manuscript; available in PMC: 2012 Jun 10.
Published in final edited form as: Cell. 2011 Jun 10;145(6):969–980. doi: 10.1016/j.cell.2011.05.022

Figure 3.

Figure 3

Structure of the Shb17/SBP complex.

(A) Overall fold of the Shb17 (H13A) in complex with SBP (PDB 3OI7, grey ribbon) shown in two orientations with secondary structural elements being labeled. The SBP molecule (magenta carbon atoms) is shown in a stick representation.

(B) Close-up view of the active site of Shb17 in complex with SBP. The side chains of residues in contact with SBP are displayed in a stick representation (green carbon atoms) and labeled. SBP is shown in a stick representation (magenta carbon atoms) and labeled, whereas the Mg2+ ion is shown as a purple sphere and labeled.

(C) Active site of Shb17 in complex with FBP, a similar view as (B). The red sphere denotes a water molecule. Y102 makes two hydrogen bonds with SBP, whereas only one hydrogen bond can be formed between this residue and FBP. These hydrogen bonds are shown by dashed lines in parts B and C.

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