Table 1.

Spearman's Rank Correlation Between an Indicator and Evolutionary Rate After Controlling for the Other Indicators.

Indicator	Before Control			After Controlk
	Alla	L-IDPsa	H-IDPsa	Alla	L-IDPsa	H-IDPsa
NmiRb	−0.298***	−0.344***	−0.293***	−0.316***	−0.329***	−0.297***
DisContc	0.113***	0.026	0.134***	0.209***	0.081***	0.197***
PPIH-IDPd	−0.196***	−0.206***	−0.241***	−0.128***	−0.10***	−0.201***
PPIL-IDPe	−0.124***	−0.156***	−0.056*	0.002	−0.028	0.074*
PPIAllf	−0.171***	−0.188***	−0.160***	0.001	−0.022	0.074*
NPhosphog	−0.060***	−0.116***	−0.021	0.001	−0.031	0.030
Expbreadthh	−0.110***	−0.153***	−0.016	−0.017	−0.055*	0.045
Explevel_xingi	−0.150***	−0.178***	−0.078**	−0.058***	−0.085***	−0.017
Explevel_Suj	−0.129***	−0.168***	−0.038	−0.049**	−0.067**	−0.044

^aAll: all proteins under study that have PPI data (5,124 proteins); L-IDPs (D_isCont < 43%; 3,300 proteins); and H-IDPs (D_isCont ≥ 43%; 1,824 proteins).

^bN_miR: The number of miRNA types that regulate the gene under study.

^cD_isCont: Disorder content, the number of disordered residues divided by protein length.

^dPPI_H-IDP: The number of H-IDPs with which a protein interacts.

^ePPI_L-IDP: The number of L-IDPs with which a protein interacts.

^fPPI_All: The total number of PPIs.

^gN_Phospho: The number of experimentally verified phosphorylation sites.

^hExp_breadth: The number of tissues that a gene is expressed in data of Su et al.

ⁱExp_{level_xing}: The average signal intensity of a gene in data of Xing et al.

^jExp_{level_Su}: The average signal intensity of a gene in data of Su et al.

^kPartial correlation between evolutionary rate and the indicator under study by controlling for N_miR, PPI_H-IDP, D_isCont, PPI_All, N_Phospho, Exp_breadth, and Exp_{level_xing}, except for the indicator under study.

Significance: *P value < 0.05, **P value ≤ 0.001, and ***P value ≤ 0.0001.