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. Author manuscript; available in PMC: 2012 Jan 14.
Published in final edited form as: Nature. 2011 Jul 13;475(7355):196–200. doi: 10.1038/nature10199

Figure 2. After C2 hemisection and implantation of a PN graft with ChABC treatment there is an increase to near-normal levels of diaphragmatic EMG activity over time.

Figure 2

a, Prior to twelve weeks post C2 hemisection there is minimal activity in the hemidiaphragm ipsilateral to the lesion in animals that received ChABC treatment and application of an autologous peripheral nerve bridge. At twelve weeks there is substantial recovery of hemidiaphragmatic inspiratory activity. b, At 12 weeks recovery in animals that received a PNG and ChABC treatment was close to that of a non-lesioned animal and better than grafted animals that received only vehicle treatment. c) Animals that received the graft and ChABC had a higher percentage of recovery 12 weeks after hemisection compared to other groups. Semi-quantitative analysis showed that there was no difference in the frequency of breaths between groups. C2 hemisected animals with a PNG and ChABC treatment (purple bars) had a higher average peak amplitude of the raw inspiratory bursts compared to the other groups. Although burst duration could, on occasion, reach near normal levels (2a,2b), on balance there was no difference in the average duration of inspiratory bursts between animals that showed recovery. Darker colored bars are all animals in a group, while the lighter bars represent only animals that showed recovered activity. ** = significantly different compared to saline and ChABC treated animals, p < 0.02. * = significantly different compared to grafted animals with saline, p < 0.05. The error bar indicates standard error.