Table 2.
Association between leptin tertiles and insulin resistance measurements in Chinese men and women aged 21–45 years.
| Males |
Females |
|||||
|---|---|---|---|---|---|---|
| 2nd tertile | 3rd tertile | lnleptin | 2nd tertile | 3rd tertile | lnleptin | |
| β(se) | β(se) | Partial R2 | β(se) | β(se) | Partial R2 | |
| HOMA-IR | ||||||
| Model A | 0.32(0.08)& | 0.71(0.09)& | 0.2084 | 0.15(0.07)* | 0.50(0.08)& | 0.2062 |
| Model B | 0.29(0.08)& | 0.56(0.09)& | 0.1181 | 0.09(0.07) | 0.41(0.08)& | 0.1342 |
| Model C | 0.20(0.07)# | 0.36(0.09)& | 0.0369 | 0.03(0.07) | 0.28(0.09)# | 0.0560 |
| Model D | 0.15(0.08) | 0.29(0.11)# | 0.0201 | 0.03(0.07) | 0.26(0.08)& | 0.0532 |
| Model E | 0.29(0.08)& | 0.57(0.09)& | 0.0996 | 0.07(0.07) | 0.34(0.08)& | 0.0887 |
| Model F | 0.17(0.07)* | 0.32(0.09)& | 0.0305 | 0.03(0.07) | 0.24(0.08)# | 0.0392 |
| FSI | ||||||
| Model A | 0.30(0.07)& | 0.66(0.08)& | 0.1989 | 0.14(0.07)* | 0.47(0.07)& | 0.2062 |
| Model B | 0.27(0.07)& | 0.52(0.08)& | 0.1116 | 0.07(0.06) | 0.37(0.07)& | 0.1269 |
| Model C | 0.19(0.07)# | 0.34(0.08)& | 0.0342 | 0.02(0.06) | 0.25(0.08)& | 0.0510 |
| Model D | 0.14(0.08) | 0.26(0.10)# | 0.0161 | 0.02(0.06) | 0.24(0.08)# | 0.0462 |
| Model E | 0.28(0.07)& | 0.53(0.08)& | 0.0961 | 0.06(0.06) | 0.31(0.07)& | 0.0828 |
| Model F | 0.17(0.07)* | 0.30(0.09)& | 0.0287 | 0.02(0.06) | 0.22(0.07)# | 0.0338 |
| 2h PI | ||||||
| Model A | 0.36(0.13)# | 0.75(0.14)& | 0.1129 | 0.12(0.07) | 0.48(0.09)& | 0.1042 |
| Model B | 0.36(0.14)# | 0.68(0.16)& | 0.0908 | 0.08(0.08) | 0.40(0.10)& | 0.0664 |
| Model C | 0.30(0.14)* | 0.59(0.19)# | 0.0549 | 0.10(0.08) | 0.43(0.11)& | 0.0595 |
| Model D | 0.10(0.13) | 0.11(0.19) | 0.0054 | 0.06(0.08) | 0.33(0.11)# | 0.0219 |
| Model E | 0.33(0.13)* | 0.58(0.17)& | 0.0569 | 0.09(0.08) | 0.39(0.10)& | 0.0512 |
| Model F | 0.31(0.14)* | 0.56(0.19)# | 0.0504 | 0.09(0.08) | 0.42(0.10)& | 0.0521 |
*
p<0.05;
#
p<0.01;
&
p<0.001 compared with 1st leptin tertile; HOMA-IR, homeostasis modeling accessible of insulin resistance; FSI, fasting serum insulin; 2h PI, 2h post-load insulin.
Model A, adjusted for age, education, occupation, active and passive smoking, alcohol consumption, and physical activity;
Model B, Model A plus Triglyceride, Cholesterol, high density lipoprotein-cholesterol(HDL-c), systolic blood pressure(SBP), diastolic blood pressure(DBP).
Model C, Model B plus body mass index(BMI);
Model D, Model B plus percentage body fat;
Model E, Model B plus percentage trunk fat;
Model F, Model B plus waist circumference.