Table 1.
DNA strand breaks in bone marrow of mice after treatment with quercetin and/or topotecan (TPT) or cyclophosphamide (mean ± SD).
| Treatment groups (mg/kg) |
Tail moment (arbitrary unit) | Tail DNA (%) |
Tail length (μm ) |
Olive tail moment (arbitrary units) |
|---|---|---|---|---|
| Control | 2.32 ± 0.40 | 6.78 ± 1.12 | 16.0 ± 4.84 | 5.18 ± 1.52 |
| Quercetin (50) | 2.68 ± 0.82 | 6.56 ± 1.67 | 14.4 ± 5.22 | 4.34 ± 0.89 |
| Quercetin (100) | 2.12 ± 0.35 | 6.62 ± 2.18 | 15.2 ± 5.40 | 3.40 ± 1.11 |
| TPT (0.5) | 7.12 ± 1.83** | 18.2 ± 3.07** | 35.0 ± 9.38* | 12.4 ± 3.28* |
| Quercetin (50) + TPT (0.5) | 3.98 ± 1.29a | 10.2 ± 1.95b | 24.4 ± 5.22 | 7.02 ± 1.53a |
| Quercetin (100) + TPT (0.5) | 2.64 ± 0.82b | 7.9 0 ± 2.57b | 16.8 ± 4.32b | 5.12 ± 1.66b |
| TPT (1) | 13.2 ± 2.27** | 22.5 ± 4.42** | 50.0 ± 6.44** | 18.0 ± 2.51* |
| Quercetin (50) + TPT (1) | 9.54 ± 1.82 | 14.6 ± 3.54a | 37.6 ± 4.27a | 10.9 ± 3.4a |
| Quercetin (100) + TPT (1) | 4.28 ± 1.52b | 11.3 ± 3.90b | 22.8 ± 6.72b | 6.88 ± 1.25b |
| Cyclophosphamide 40 | 23.9 ± 4.57# | 26.0 ± 6.17# | 64.2 ± 6.76# | 14.58 ± 1.93# |
*P < 0.05 and **P < 0.01 versus control (Kruskal-Wallis test followed by Dunn's multiple comparisons test). a P < 0.05 and b P < 0.01 versus the corresponding TPT alone; # P < 0.01 versus control (Mann-Whitney U test).