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. Author manuscript; available in PMC: 2011 Dec 30.
Published in final edited form as: Nature. 2011 Jun 29;474(7353):609–615. doi: 10.1038/nature10166

Figure 2. Gene and miRNA expression patterns of molecular subtype and outcome prediction in HGS-OvCa.

Figure 2

(a) Tumors from TCGA and Tothill et al. separated into four clusters, based on gene expression. (b) Using a training dataset, a prognostic gene signature was defined and applied to a test dataset. (c) Kaplan-Meier analysis of four independent expression profile datasets, comparing survival for predicted higher risk versus lower risk patients. Univariate Cox p-value for risk index included. (d) Tumors separated into three clusters, based on miRNA expression, overlapping with gene-based clusters as indicated. (e) Differences in patient survival among the three miRNA-based clusters.