Table 2. Significantly mutated genes in HGS-OvCa.
| Gene | Number of Mutations |
Validated | Unvalidated |
|---|---|---|---|
| TP53 | 302 | 294 | 8 |
| BRCA1 | 11 | 10 | 1 |
| CSMD3 | 19 | 19 | 0 |
| NF1 | 13 | 13 | 0 |
| CDK12 | 9 | 9 | 0 |
| FAT3 | 19 | 18 | 1 |
| GABRA6 | 6 | 6 | 0 |
| BRCA2 | 10 | 10 | 0 |
| RB1 | 6 | 6 | 0 |
Validated mutations are those that have been confirmed with an independent assay. Most of them are validated using a second independent WGA sample from the same tumor. Unvalidated mutations have not been independently confirmed but have a high likelihood to be true mutations. An additional 25 mutations in TP53 were observed by hand curation.