Table 2.
Evolution of antiretroviral resistance mutations in HIV-1 individuals with dual infections
| Case | Time points | Primary subtype | Secondary subtype | ||
|---|---|---|---|---|---|
| Prot | RT | Prot | RT | ||
| C1 | B subtype | BF recombinant (not CRF12) | |||
| S1 | NONE | M41L/M184V/Y188L/L210W/T215Y21 V106I, H221Y and D67N (A) |
NONE | NONE | |
| S2 | L10I/I15V/M46I/L63P/I84V/I85V/L90M12 M36I and F53L/A71T(A) |
M41L/D67N/L210W/T215Y12 | NON DETECTED | ||
| C2 | CRF12_BF | B subtype | |||
| NONE | NONE | I84V/L90M | M41L/K70E/L210W/T215Y | ||
| C3 | B subtype | CRF12_BF | |||
| NONE | K103N1 | NONE | NONE | ||
| C4 | CRF12_BF | B subtype | |||
| S1 | I47V1 | NONE | NONE | NONE | |
| S2 | NONE | K70R1 | NON DETECTED | ||
| C5 | CRF12_BF | BF recombinant (not CRF12) | |||
| S1 | NONE | Y181C/H221Y2 | NON DETECTED | ||
| S2 | NONE | Y181C1 | NONE | NONE | |
A mean of sixteen sequences and/or clones per sample were analyzed with Stanford software. Resistance mutations separeted by bars indicate combination of mutations in the sequences. The number indicated by superscript shows the number of sequences or clones with the corresponding mutation or combination of mutations.
(A) Each mutation in different sequences and carrying the combination of mutations indicated.