Figure 10. Cx43 deficient mice display increased bone resorption and osteoclast number.

Four week old Cx43 deficient mice show increased osteoclast number in the distal epiphyseal area (A) and increased serum CTX concentration (B). n = 4 (A) or 3–9 (B) mice per group, * p<0.05. C–E: Typical TRAP staining of four-week old wild type (WT) (C and D) and Cx43 deficient (KO) (E and F) mouse femur. There are more osteoclasts in bone from Cx43 deficient mice. Scale bar = 100 µm.