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. 2000 Feb 1;14(3):272–277.

Figure 4.

Figure 4

Figure 4

Figure 4

Figure 4

LOH at the CBP locus in tumors. Southern blot analysis of tumors isolated from a mediastinal mass in an animal with myelogenous leukemia (A) (Table 2, mouse 18); HS arising in a WT recipient transplanted with bone marrow from a CBP+/− mouse (B); and plasmacytomas arising in multiple recipients (T2, T5, T6) of bone marrow from a CBP+/− mouse (C). Comparisons are made to WT, and CBP+/− controls. Expected WT and targeted mutant (MUT) alleles are indicated by arrows. (D) p300 and CBP Western blot analysis of protein extracts from plasmacytomas arising in multiple transplant recipients (T2, T5, T6), compared with equivalent amounts of protein extract from spleens of WT and CBP+/− controls.