Table II.
Activity for GSK923295A against the PPTP in Vivo Panel
| Xenograft Line | Histology | KM Estimate of Median Time to Event | P-value | EFS T/C | Median Final RTV | T/C | P-value | T/C Activity | EFS Activity | Response Activity |
|---|---|---|---|---|---|---|---|---|---|---|
| BT-29 | Rhabdoid | 38.5 | <0.001 | 2.8 | >4 | 0.34 | <0.001 | Int | Int | Int |
| KT-14 | Rhabdoid | > EP | <0.001 | > 2.0 | 0 | 0.11 | <0.001 | High | High | High |
| KT-12 | Rhabdoid | > EP | <0.001 | > 4.5 | 0 | 0 | <0.001 | High | High | High |
| KT-11 | Wilms | > EP | <0.001 | > 4.0 | 0 | 0 | <0.001 | High | High | High |
| KT-13 | Wilms | > EP | <0.001 | > 3.5 | 0.7 | 0.34 | <0.001 | Int | High | High |
| SK-NEP-1 | Ewing | > EP | <0.001 | > 6.1 | 0 | 0.05 | <0.001 | High | High | High |
| EW5 | Ewing | 13.4 | <0.001 | 1.6 | >4 | 0.52 | <0.001 | Low | Low | Int |
| EW8 | Ewing | > EP | <0.001 | > 4.0 | 0 | 0.11 | <0.001 | High | High | High |
| TC-71 | Ewing | > EP | <0.001 | > 6.4 | 1.7 | 0.15 | <0.001 | High | Int | High |
| CHLA258 | Ewing | 25.7 | <0.001 | 3.8 | >4 | 0.44 | <0.001 | Int | Int | Int |
| Rh10 | ALV RMS | > EP | <0.001 | > 2.8 | 0 | 0.14 | <0.001 | High | High | High |
| Rh30 | ALV RMS | 23.9 | 0.217 | 1.9 | >4 | 0.52 | 0.043 | Low | Low | Int |
| Rh30R | ALV RMS | 34.2 | <0.001 | 3.2 | >4 | 0.61 | 0.003 | Low | Int | Int |
| Rh41 | ALV RMS | 18.6 | <0.001 | 1.5 | >4 | 0.57 | <0.001 | Low | Low | Int |
| Rh18 | EMB RMS | > EP | <0.001 | > 3.6 | 0 | 0.1 | <0.001 | High | High | High |
| BT-28 | Medulloblastoma | 4.1 | 0.974 | 0.8 | >4 | 1.29 | 0.739 | Low | Low | Low |
| BT-45 | Medulloblastoma | 15.3 | 0.068 | 1.2 | >4 | 0.8 | 0.247 | Low | Low | Low |
| BT-50 | Medulloblastoma | > EP | 0.002 | > 1.3 | 0.8 | 0.63 | 0.024 | Low | NE | Int |
| BT-36 | Ependymoma | > EP | 0.011 | > 1.6 | 1.5 | 0.48 | 0.007 | Low | NE | Int |
| BT-44 | Ependymoma | > EP | <0.001 | > 2.8 | 0.2 | 0.05 | <0.001 | High | High | High |
| GBM2 | Glioblastoma | 34.2 | <0.001 | 2.7 | >4 | 0.11 | <0.001 | High | Int | Int |
| BT-39 | Glioblastoma | > EP | <0.001 | > 4.0 | 2.4 | 0.78 | 0.315 | Low | Int | Int |
| D456 | Glioblastoma | > EP | <0.001 | > 6.7 | 0 | 0.02 | <0.001 | High | High | High |
| NB-SD | Neuroblastoma | > EP | <0.001 | > 5.7 | 3.6 | 0.38 | 0.021 | Int | Int | Int |
| NB-1771 | Neuroblastoma | 9.2 | 0.002 | 1.9 | >4 | 0.43 | 0.002 | Int | Low | Int |
| NB-1691 | Neuroblastoma | 11.3 | <0.001 | 2 | >4 | 0.37 | <0.001 | Int | Low | Int |
| NB-EBc1 | Neuroblastoma | 15.9 | <0.001 | 2.3 | >4 | 0.5 | <0.001 | Low | Int | Int |
| NB-1643 | Neuroblastoma | 14.5 | 0.006 | 2.6 | >4 | 0.22 | 0.002 | Int | Int | Int |
| SK-N-AS | Neuroblastoma | 6.1 | 0.056 | 1.2 | >4 | 0.67 | 0.052 | Low | Low | Low |
| OS-1 | Osteosarcoma | > EP | <0.001 | > 1.4 | 1.9 | 0.49 | <0.001 | Low | NE | Int |
| OS-2 | Osteosarcoma | > EP | <0.001 | > 1.2 | 0.8 | 0.61 | 0.001 | Low | NE | High |
| OS-17 | Osteosarcoma | > EP | <0.001 | > 1.4 | 1.7 | 0.7 | 0.024 | Low | NE | Int |
| OS-9 | Osteosarcoma | > EP | <0.001 | > 2.2 | 2.6 | 0.44 | <0.001 | Int | Int | Int |
| OS-33 | Osteosarcoma | > EP | <0.001 | > 2.7 | 1.1 | 0.26 | <0.001 | Int | Int | High |
| OS-31 | Osteosarcoma | > EP | <0.001 | > 3.0 | 1.2 | 0.4 | <0.001 | Int | Int | Int |