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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Nat Genet. 2011 Aug 14;43(9):883–886. doi: 10.1038/ng.908

Figure 1.

Figure 1

Alignment of the motif regions in ACSF3 orthologues and the malonyl-CoA synthase enzymes in bacteria. The sequences (see methods) were aligned using MegAlign via the Clustal W method. An additional three amino acids amino-terminal to Motif I are shown. Motif II was aligned independent of the full-length protein to improve the alignment of the ACSF3 and MCS proteins. The ACSF3 alterations identified in the eight subjects and affected dog are indicated. The asterisk (*) indicates the dog variant p.Gly430Ser, which is orthologous to position p.Gly480 in human ACSF3.