Table 1.

Selected differentially regulated genes between Setleis syndrome patient fibroblasts and normal control Fibroblasts using human Affymetrix 3′IVT expression arrays. Microarray data files can be found at the National Center for Biotechnology Information (NCBI GEO #GES16524).

Gene	MA Fold change	Modified t/p-value	Median RT-PCR fold change	Function
LAMA4, laminin α4	+3.7	+19.9/0.009	+4.7	Major non-collagenous constituent of basement membranes
POSTN, periostin	−61	−8.8/0.009	−134	Cell adhesion protein. Has been shown to be regulated by Twist1.
COL15A1, collagen15A1	−62	−13.12/0.011	−4.7	Adheres to basement membranes and to underlying connective tissue stroma.
IL7, interleukin 7	+11	+35.8/0.015	+2.7	Plays an essential role in lymphoid cell survival.