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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Int J Biochem Cell Biol. 2011 Jun 12;43(10):1432–1441. doi: 10.1016/j.biocel.2011.05.016

Figure 2.

Figure 2

D2 is a dimeric selenoenzyme ubiquitinated by WSB-1 and TEB4 complexes. (A) Ultra-structure of the D2:D2 dimer inserted into the ER membrane. Reproduced from (Sagar et al., 2007). (B) Detailed structure of the globular domain of D2. White asterisk marks the instability loop. Modified from (Dentice et al., 2005). In (C), newly synthesiZed D2 is targeted to the ER membrane, where D2 ubiquitination is triggered by T4-to-T3 catalysis. Ubiquitinated D2 (Ub-D2) is shuttled to the proteasomes. D2 can be rescued from terminal destruction via two DUBs: ubiquitin-specific proteases USP-20 and USP-33.