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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Gastroenterology. 2011 May 18;141(3):1003–1013.e10. doi: 10.1053/j.gastro.2011.05.007

Figure 2.

Figure 2

Mutant Kras activation promotes increased goblet cells and Paneth cell loss, via RAS-MAPK-dependent signaling. Paneth cells, with lysozyme staining (left side, panels A and B) and goblet cells, with Alcian Blue staining (right side, panels A and B) in ileum. Scale bars, 100 μm. (C) Ratio of goblet cells vs. enterocytes in ileal crypts following CI-1040 treatment. (D and E) Recovery of Paneth cells in ileum of G22Cre KrasLSL-G12D mice following CI-1040 treatment. Scale bars, 50 μm. Arrowheads indicate lysozyme-positive Paneth cells. (F) Quantification of Paneth cells from G22Cre KrasLSL-G12D mice treated with vehicle or CI-1040. *P < .001.

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