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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Leuk Res. 2011 Jul 8;35(10):1402–1408. doi: 10.1016/j.leukres.2011.06.018

Figure 5. Plumbagin sensitizes human chronic myelogenous leukemia cells to TRAIL-induced apoptosis.

Figure 5

The effect of plumbagin on soluble TRAIL-mediated apoptosis in K562 was examined. To this end, K562 were treated with various concentrations of plumbagin (0 or 1 µM) in combination with various concentrations of soluble TRAIL (0–50 ng/ml). The tumor cells were harvested 24 hours later and the viable cell number and the induction of apoptosis were determined by Trypan blue dye exclusion (Figure 5A) and cell cycle analysis (Figure 5B), respectively. The data represent the mean ± SD. Asterisk denotes statistically significant difference (p<0.05) between vehicle (0 µM PLB) and plumbagin treated cells. Cell cycle analysis data represent the percentage of apoptotic cells (Sub G0) from a representative experiment.