Table 1.
Established biochemical and functional features of human sirtuins. (Adapted from Albani et al., 2010)9 and reprinted with permission from IOS Press.
| Sirtuin | Cell Localization | Activity/Key Targets |
|---|---|---|
| Sirt1 | Nucleus | Deacetylase/p53, FOXO3, RARβ, PGC1-α, PPAR-γ, NFκB, IGF-1, Histone H1, H3, H4 |
| Sirt2 | Cytoplasm | Deacetylase/Histone H4, α-tubulin |
| Sirt3 | Mitochondria | Deacetylase and ART*/Ku70, Acetyl-CoA synthetase, Glutamate dehydrogenase, Isocitrate dehydrogenase |
| Sirt4 | Mitochondria | ART/Glutamate dehydrogenase |
| Sirt5 | Mitochondria | Deacetylase/Cytochrome-c |
| Sirt6 | Nucleus | Deacetylase and ART/Histone H3 |
| Sirt7 | Nucleus | Deacetylase (?)/RNA PolI complex (?) |
*
ART = ADP-ribosyltransferase activity