Table 2.
Prevalence of pfmdr1 copy number in isolates collected from malaria patients with sensitive, re-infection, and recrudescence (before treatment and at the time of reappearance) responses, Thailand*
Pfmdr1 copy number | Treatment outcome, no. (%) | |||
---|---|---|---|---|
Sensitive† (n = 87) | Failure (n = 30) | |||
Re-infection (n = 9) | Recrudescence‡ | |||
Pre-treatment (n = 21) | Post-treatment (n = 18) | |||
1 | 64 (73.6) | 8 (88.9) | 12 (57.1) | 4 (22.2) |
2 | 12 (13.8) | 1 (11.1) | 2 (9.5) | 2 (11.1) |
3 | 7 (8.0) | 0 (0.0) | 1 (4.8) | 4 (22.2) |
4 | 4 (4.6) | 0 (0.0) | 3 (14.3) | 5 (27.8) |
5 | 0 (0.0) | 0 (0.0) | 1 (4.8) | 0 (0) |
6 | 0 (0.0) | 0 (0.0) | 2 (9.5) | 2 (11.1) |
7 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0) |
8 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (5.6) |
Pfmdr1 = P. falciparum multidrug resistance 1.
Statistically significant difference from pre-treatment recrudescence (P = 0.007).
Statistically significant difference between pre-treatment and post-treatment recrudescence (P = 0.007).